Table 6.
Factors associated with ESBL-PE neonatal sepsis among 304 neonates with clinical sepsis at BMC.
| Variable | ESBL Positive | ESBL Negative | OR [95% CI] | p-value | OR [95% CI] | p-value |
|---|---|---|---|---|---|---|
| Median/ n (%) | Median/ n (%) | |||||
| Age in days | 6 IQR (4-8) | 5 IQR (3-10) | 0.94 [0.88 - 1.02] | 0.139 | 0.93 [0.87-1.02] | 0.117 |
| Sex | ||||||
| Female | 17 (8.9) | 175 (91.15) | 1 | |||
| Male | 15 (13.4) | 97 (86.6) | 1.59 [0.76 - 3.33] | 0.217 | 1.5 [0.69-3.4] | 0.286 |
| Gestation age | 38 IQR (36-40) | 39 IQR (37-40) | 1.33 [0.58-3.01] | 0.501 | ||
| Body weight | 2.7 IQR (2.3-3) | 2.9 IQR (2.1-3.3) | 0.79 [0.48-1.29] | 0.348 | ||
| Admission | ||||||
| BMC | 15 (12.9) | 101 (87.1) | 1 | |||
| Referral | 17 (9.04) | 171 (90.9) | 0.7 [0.3-1.4] | 0.286 | ||
| Poor feeding | ||||||
| No | 19 (11.6) | 145 (88.4) | 1 | |||
| Yes | 13 (9.3) | 127 (90.7) | 1.28 [0.61 - 2.69] | 0.516 | ||
| Convulsions | ||||||
| No | 27 (10.3) | 236(89.7) | 1 | |||
| Yes | 5 (12.2) | 36 (87.8) | 1.21 [0.44 - 3.36] | 0.709 | ||
| Skin pustule | ||||||
| No | 27 (10.5) | 230 (89.5) | 1 | |||
| Yes | 5 (10.6) | 42(89.4) | 1.01 [0.36 - 2.78] | 0.978 | ||
| Lethargy | ||||||
| No | 19 (9.6) | 178 (90.3) | 1 | |||
| Yes | 13 (12.2) | 94 (87.9) | 1.3 [0.61 – 2.74] | 0.498 | ||
| Antibiotic use | ||||||
| No | 18 (8.11) | 204 (91.9) | 1 | |||
| Yes | 14 (17.1) | 68 (82.9) | 2.33 [1.1-4.94] | 0.027 | 1.84 [0.82-4.12] | 0.139 |
| Admission | ||||||
| PREM | 23 (8.7) | 242 (91.3) | 1 | |||
| NICU | 9 (23.1) | 30 (79.9 | 3.16 [1.34-7.45] | 0.009 | 3.02 [1.19-7.69] | 0.021 |
| Swab ESBL | ||||||
| No | 6 (4.35) | 132 (95.7) | 1 | |||
| Yes | 26 (15.7) | 140 (84.3) | 4.09 [1.62-10.24] | 0.003 | 3.08 [1.19-7.99] | 0.021 |
| Stool ESBL | ||||||
| No | 15 (6.9) | 203 (93.1) | 1 | |||
| Yes | 17 (19.8) | 69 (80.23) | 3.33 [1.58-7.03] | 0.002 | 2.87 [1.3-6.33] | 0.009 |
| Maternal fever | ||||||
| No | 10 (9.5) | 95 (90.5) | 1 | |||
| Yes | 22 (11.1) | 177 (88.9) | 1.18 [0.53-2.59] | 0.679 | ||
| PROM | ||||||
| No | 22 (10.6) | 186 (89.4) | 1 | |||
| Yes | 10 (10.4) | 86 (89.6) | 0.98 [0.44-2.17] | 0.966 | ||
| Maternal antibiotics | ||||||
| No | 16 (10.1) | 143 (89.9) | 1 | |||
| Yes | 16 (11) | 129 (88.9) | 1.11 [0.53-2.31] | 0.783 |