Table 7.
Factors associated with neonatal ESBL-PE colonization among 304 neonates with clinical sepsis at BMC.
| Variable | ESBL Positive | ESBL Negative | OR [95% CI] | p-value | OR [95% CI] | p-value |
|---|---|---|---|---|---|---|
| Median/ n (%) | Median/ n (%) | |||||
| Age in days | 6 IQR (3-10) | 5 IQR (3-9) | 1.01 [0.98 - 1.05] | 0.529 | ||
| Sex | ||||||
| Female | 60 (53.6) | 52 (46.4) | 1 | |||
| Male | 106 (55.2) | 86 (44.8) | 0.94 [0.59 - 1.49] | 0.782 | ||
| Admission | ||||||
| BMC | 60 (51.7) | 56 (48.3) | 1 | |||
| Referral | 106 (56.4) | 82 (43.6) | 1.2 [0.8-1.9] | 0.428 | ||
| Birth weight (kg) | 2.9 IQR (2.3-3.3) | 2.8 IQR (2.1-3.2) | 1.07 [0.79-1.44] | 0.654 | ||
| Body temperature | 37.85 IQR (37-38) | 37.85 IQR (37-38.3) | 0.96 [0.81-1.15] | 0.662 | ||
| Oxygen Sat (%) | 93 IQR (91-96) | 93 IQR (88-96) | 1.02 [0.99-1.05] | 0.211 | 1.03 [0.99-1.06] | 0.113 |
| Skin pustule | ||||||
| No | 140 (54.5) | 117 (45.5) | 1 | |||
| Yes | 26 (55.3) | 21 (44.7) | 1.03 [0.55 - 1.93] | 0.915 | ||
| Umbilical discharge | ||||||
| No | 132 (54.3) | 111 (45.7) | 1 | |||
| Yes | 34 (55.7) | 27 (44.3) | 1.06 [0.61-1.86] | 0.843 | ||
| History of antibiotic-baby | ||||||
| No | 112 (50.5) | 110 (49.6) | 1 | |||
| Yes | 54 (65.9) | 28 (34.2) | 1.89 [1.12-3.21] | 0.017 | 1.73 [1-2.97] | 0.048 |
| Admission | ||||||
| PREM | 141 (53.2) | 124 (46.8) | 1 | |||
| NICU | 25 (64.1) | 14 (35.9) | 1.57 [0.78-3.15] | 0.205 | 1.89 [0.9-3.95] | 0.092 |
| Maternal fever | ||||||
| No | 56 (53.3) | 49 (46.7) | 1 | |||
| Yes | 110 (55.3) | 89 (44.7) | 1.08 [0.67-1.73] | 0.746 | ||
| PROM | ||||||
| No | 116 (56) | 91 (43.9) | 1 | |||
| Yes | 50 (51.6) | 47 (48.5) | 0.83 [0.51-1.35] | 0.464 | ||
| Maternal antibiotics | ||||||
| No | 82 (51.6) | 77 (48.4) | 1 | |||
| Yes | 84 (57.9) | 61 (42.1) | 1.29 [0.82-2.03] | 0.266 | 1.08 [0.67-1.75] | 0.739 |
| Stool ESBL | ||||||
| No | 107 (49.1) | 111 (50.9) | ||||
| Yes | 59 (68.6) | 27 (31.4) | 2.27 [1.34-3.84] | 0.002 | 2.19 [1.26-3.79] | 0.005 |