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. 2018 Oct;153:86–98. doi: 10.1016/j.biochi.2018.06.020

Table 1.

Concentrations of dihydroxy-3-oxocholest-4-en-26-oic acids in CSF.

Compound Control CSF, n = 42
CTX CSF, n = 6
SPG5 CSF, n = 3
Mean
Median
SD
Mean
Median
SD
Significance1
Mean
Median
SD
Significance1
ng/mL ng/mL ng/mL ng/mL ng/mL ng/mL CTX v Control ng/mL ng/mL ng/mL SPG5 v Control
CA4-7α,24-diol-3-one 0.30 0.30 0.08 0.10 0.10 0.02 P < 0.01 0.07 0.09 0.07 P < 0.01
CA4-7α,x-diol-3-one 5.83 5.65 1.49 ND ND NA P < 0.01 0.60 0.27 0.66 P < 0.01
CA4-7α,25-diol-3-one 1.60 1.51 0.44 ND ND NA P < 0.01 0.192 0.05 0.27 P < 0.01
(25 R)CA4-7α,12α-diol-3-one 1.11 0.82 1.10 0.49 0.29 0.60 P < 0.05 0.64 0.72 0.17 P > 0.05
(25 S)CA4-7α,12α-diol-3-one ND ND NA 0.12 0.09 0.11 P < 0.01 ND ND NA NA

Quantification was made utilising LC-HRMS RICs with [2H7]22 R-hydroxycholest-4-en-3-one as the internal standard.

1. Mann-Whitney test.

2. From Ref. [9].

ND = not detected.

NA = not available.