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. 2018 Oct;153:86–98. doi: 10.1016/j.biochi.2018.06.020

Table 2.

Concentrations of dihydroxy-3-oxocholest-4-en-26-oic acids in plasma.

Compound Control plasma1, n = 24
CTX plasma, n = 13
SPG5 plasma
Mean
Median
SD
Mean
Median
SD
Significance2
P1
P2
ng/mL ng/mL ng/mL ng/mL ng/mL ng/mL CTX v Control ng/mL ng/mL
CA4-7α,24-diol-3-one 0.05 0.04 0.04 0.15 0.06 0.19 P > 0.05 0.23 0.15
CA4-7α,x-diol-3-one 0.92 0.89 0.30 ND ND NA P < 0.01 0.33 0.20
CA4-7α,25-diol-3-one ND ND NA ND ND NA NA ND ND
(25 R)CA4-7α,12α-diol-3-one 1.56 1.38 1.24 0.29 0.03 0.43 P < 0.01 1.91 0.78
(25 S)CA4-7α,12α-diol-3-one ND ND NA 0.08 0.03 0.12 P < 0.01 ND ND

Quantification was made utilising LC-HRMS RICs with [2H7]22 R-hydroxycholest-4-en-3-one as the internal standard.

1.Data from Abdel-Khalik et al. [10].

2.Mann-Whitney test.