Table 2.

Concentrations of dihydroxy-3-oxocholest-4-en-26-oic acids in plasma.

Compound	Control plasma1, n = 24			CTX plasma, n = 13				SPG5 plasma
	Mean	Median	SD	Mean	Median	SD	Significance2	P1	P2
	ng/mL	ng/mL	ng/mL	ng/mL	ng/mL	ng/mL	CTX v Control	ng/mL	ng/mL
CA4-7α,24-diol-3-one	0.05	0.04	0.04	0.15	0.06	0.19	P > 0.05	0.23	0.15
CA4-7α,x-diol-3-one	0.92	0.89	0.30	ND	ND	NA	P < 0.01	0.33	0.20
CA4-7α,25-diol-3-one	ND	ND	NA	ND	ND	NA	NA	ND	ND
(25 R)CA4-7α,12α-diol-3-one	1.56	1.38	1.24	0.29	0.03	0.43	P < 0.01	1.91	0.78
(25 S)CA4-7α,12α-diol-3-one	ND	ND	NA	0.08	0.03	0.12	P < 0.01	ND	ND

Quantification was made utilising LC-HRMS RICs with [²H₇]22 R-hydroxycholest-4-en-3-one as the internal standard.

1.Data from Abdel-Khalik et al. [10].

2.Mann-Whitney test.