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. 2018 Sep 6;3(17):e120824. doi: 10.1172/jci.insight.120824

Figure 4. Subretinal deposits contain lipid globules and degenerative vacuoles.

Figure 4

(A) Representative optical coherence tomography (OCT) images of 12-month-old Abca1/g1F/F and Abca1/g1–m/–m mice retinas. Note the subretinal hyperreflective deposits in Abca1/g1–m/–m mice retinas (red arrow) corresponding to fundus yellowish white dots. POS, photoreceptor outer segment. (B) Quantification of subretinal deposits in 3-, 6-, and 12-month-old Abca1/g1F/F and Abca1/g1–m/–m mice retinas. Abca1/g1F/F, n = 10, 10, and 15; Abca1/g1–m/–m, n = 13, 24, and 16, respectively. ***P < 0.001 by 2-way ANOVA with post hoc Bonferroni’s multiple comparison test. (C) Representative electron microscopy images of 12-month-old Abca1/g1F/F and Abca1/g1–m/–m mice retinas. Note the vacuoles (asterisk) and lipid globules (red arrowheads) within the subretinal deposit in Abca1/g1–m/–m mice retinas. Scale bar: 1 μm. Values are mean ± SEM.