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. 2018 Sep 6;3(17):e120750. doi: 10.1172/jci.insight.120750

Figure 2. JAK/STAT-related genes are highly expressed in cyclosporine A–exposed organ transplant recipients.

Figure 2

(A) NanoString gene expression analysis was performed on mRNA extracted from 45 samples with varying histology and clinical features: normal tissue (N, n = 7), superficial squamous cell carcinoma (SCC) (S, n = 6), locally invasive SCC (I, n = 12), SCC with PNI (P, n = 10), and SCC from immunosuppressed transplant patients (T, n = 10). Heatmap displaying IL-22 and downstream related gene expression by diagnosis group. (B) Normalized expression values for JAK/STAT genes from NanoString classified by Brigham and Woman’s Hospital’s (BWH’s) staging system (as described previously, ref. 70) (mean with SD). *P < 0.05, determined by 1-way ANOVA with Dunnett’s multiple comparisons test.