Figure 3. Effect of polygenic risk scores on weight loss trajectory groups.

(A) Histograms displaying the different distribution of polygenic risk scores PRS₁₈₆ and PRS₁₁ in patients assigned to LWL or HWL+NWL trajectory groups. As shown, increasing values of PRS₁₈₆ and PRS₁₁ are significantly associated with a greater probability of being in the LWL group. Odds ratios (OR) and P values are for the linear trend test in the multivariable binary logistic model. HWL, NWL, and HWL: high-, normal-, and low-weight-loss trajectory groups. (B) Graphical representation of the area under the ROC curve (AUC) for PRS₁₈₆ and PRS₁₁. The AUC for initial BMI (iBMI) is also shown. (C) Impact of maximum (red lines) and minimum (green lines) values of PRS₁₈₆ and PRS₁₁ on the probability of being in the LWL group as a function of iBMI (gray lines). Gray, red, and green shaded areas represent 95% confidence intervals. (D) The AUC of the final logistic prediction models, including all the demographic and clinical predictors before (Final Model: sex, age, type of surgery, and iBMI) and after the inclusion of polygenic risk scores (Model + PRS₁₈₆ and Model + PRS₁₁) are shown.