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. 2018 Sep 6;3(17):e120182. doi: 10.1172/jci.insight.120182

Figure 4. NMN increases NAMPT and NMNAT3 expression following hemorrhagic shock.

Figure 4

Following hemorrhagic shock, there was a trend toward increased NAMPT mRNA expression that was further enhanced with NMN treatment in the kidney (A) and the liver (E). NAMPT protein expression was not affected by shock in either tissue (B and F). NMNAT1 expression was not affected in the kidney (C) but declined following shock and resuscitation in the liver and was not affected by NMN (G). NMNAT3 expression was increased in the kidney and decreased in the liver following shock but was enhanced in both tissues by NMN treatment only in animals that had been shocked (D and H). n = 5–12 per treatment group. Data are represented using box-and-whisper plots, with boxes representing the IQR, lines representing the median value, and whiskers representing minimum and maximum values. One-way ANOVA was used to compare groups with a post hoc 2 tailed Student’s t or Mann-Whitney test if statistically significant.*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.