Table 4. Assessment of inner and outer retinal layer metrics on the cirrus HD-OCT platform in normal eyes. Comparison across quartiles.
| Metric | Quartile 1 (Age 10–30) Average (standard deviation, range) |
Quartile 2 (Age 31–50) Average (standard deviation, range) |
Quartile 3 (Age 51–70) Average (standard deviation, range) |
Quartile 4 (Age 71–85) Average (standard deviation, range) |
P value | |
|---|---|---|---|---|---|---|
| Total Retina (ILM-RPE) | Central thickness | 203.38 (20.57, 166.2 to 263.9) | 201.65 (16.23, 158.4 to 230.7) | 199.16 (19.53, 161.2 to 264) | 198.156 (20.57, 164.2 to 236.5) | 0.63 |
| Juxtafoveal nasal thickness | 330.83 (19.3, 285.4 to 373.5) | 330.89 (14.93, 304.9 to 365.7) | 324.25 (20.88, 267.8 to 397.1) | 323.2 (17.78, 275.6 to 350) | 0.14 | |
| Juxtafoveal temporal thickness | 312.04 (16.78, 279.6 to 353.9) | 312.14 (13.96, 291.3 to 342.1) | 303.50 (18.28, 261.9 to 383.3) | 305.3 (21.1, 250.9 to 338.2) | 0.03 | |
| Inner Retina (ILM-OPL) | Central thickness | 29.38 (13.5, 7.8 to 62.6) | 23.79 (13.99, 3.9 to 66.5) | 17.9 (12.44, 0.9 to 78.2) | 14.5 (8.82, 0 to 41.1) | <0.001 |
| Juxtafoveal nasal thickness | 210.23 (21.52, 176 to 260) | 206.64 (20.25, 168.1 to 254.2) | 194.24 (24.59, 140.8 to 287.7) | 199.1 (24.4, 138.8 to 230.7) | 0.003 | |
| Juxtafoveal temporal thickness | 182.58 (14.84, 142.7 to 213.1) | 180.40 (21.09, 148.3 to 234.6) | 168.97 (15.77, 134.9 to 205.3) | 167.81 (21.81, 103.6 to 205.3) | <0.001 | |
| Outer Retina (ONL/HFL-RPE) | Central thickness | 174 (17.9, 129.1 to 209.2) | 177.86 (16.64, 134.9 to 205.3) | 181.28 (18.02, 125.2 to 228.8) | 183.65 (22.08, 136.9 to 220.9) | 0.13 |
| Juxtafoveal nasal thickness | 120.6 (19.47, 84 to 166.2) | 124.25 (17.47, 88 to 154.4) | 130.01 (17.7, 86 to 164.2) | 124.10 (18.33, 86 to 160.3) | 0.07 | |
| Juxtafoveal temporal thickness | 129.46 (11.38, 103.6 to 150.5) | 131.73 (16.63, 84.1 to 162.2) | 134.53 (16.95, 99.7 to 172.1) | 137.50 (19.78, 69.1 to 166.2) | 0.2 | |
| Ellipsoid Zone | Central thickness | 50.22 (6.44, 41.1 to 62.6) | 52.46 (6.26, 43 to 68.4) | 50.38 (5.89, 37.1 to 66.5) | 49.0 (4.75, 39.1 to 58.7) | 0.14 |
| Juxtafoveal nasal thickness | 33.80 (6.63, 19.6 to 48.9) | 35.29 (5.10, 25.4 to 46.9) | 35.48 (5.02, 27.4 to 46.9) | 34.8 (5.4, 25.4 to 48.9) | 0.48 | |
| Juxtafoveal temporal thickness | 32.32 (5.52, 23.5 to 48.9) | 33.61 (6.0, 21.5 to 48.9) | 33.89 (5.57, 21.5 to 58.7) | 33.54 (4.32, 25.4 to 43) | 0.54 | |
| Area and Volume measurements | ONL to EZ central foveal area | 0.54 (0.05, 0.43 to 0.63) | 0.54 (0.04, 0.45 to 0.63) | 0.56 (0.06, 0.455 to 0.73) | 0.56 (0.04, 0.46 to 0.63) | 0.10 |
| ONL to EZ volume | 2.84 (0.2, 2.42 to 3.36) | 2.86 (0.20, 2.45 to 26) | 2.89 (0.27 (2.4 to 3.58) | 2.91 (0.16, 2.54 to 3.17) |
0.55 | |
| EZ to RPE central foveal area | 0.20 (0.03, 0.16 to 0.31) | 0.21 (0.02, 0.16 to 0.28) | 0.21 (0.02, 0.16 to 0.3) | 0.21 (0.01, 0.17 to 0.23) | 0.70 | |
| EZ to RPE volume | 1.20 (0.14, 1.0 to 1.68) | 1.19 (0.09, 1.04 to 1.38) | 1.21 (0.10, 0.98 to 1.6) | 1.19 (0.07, 0.96 to 1.31) | 0.65 | |
| ONL to RPE central foveal area | 0.75 (0.05, 0.62 to 0.87) | 0.75 (0.05, 0.6 to 0.86) | 0.77 (0.06, 0.65 to 0.96) | 0.77 (0.04, 0.67 to 0.84) | 0.09 | |
| ONL to RPE volume | 4.04 (0.25, 3.6 to 4.84) | 4.05 (0.26, 3.6 to 4.65) | 4.10 (0.31, 3.53 to 4.8) | 4.11 (0.19, 3.66 to 4.40) | 0.55 | |
| En face Ellipsoid Zone mapping | Attenuation (20 um) | 1.58 (1.44, 0.04 to 4.93) | 1.08 (1.29, 0.018 to 4.67) | 0.44 (0.65, 0.01 to 3.8) | 0.47 (0.47, 0.01 to 1.71) | <0.001 |
| Loss (0 um) | 0.10 (0.11, 0 to 0.42) | 0.13 (0.21, 0 to 28) | 0.12 (0.12, 0 to 0.62) | 0.13 (0.12, 0 to 0.41) | 0.75 |