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. 2018 Oct 4;13(10):e0204976. doi: 10.1371/journal.pone.0204976

Fig 5. MIEN1 knockout cell characterization.

Fig 5

(A) Cell morphology. Representative 10x magnification phase contrast images of MIEN1 KO cells and corresponding parental cells. (B) MTT assay comparing fold change of proliferation of 4175-WT and 4175-MKO cells. (C) MTT assay comparing fold change of cell survival during serum deprivation of 4175-WT and 4175-MKO cells. (*p-value <0.05. ***p-value <0.005) (D) Spheroid formation. Representative 4x magnification phase contrast images of spheroid growth in Matrigel for 4175-WT and 4175-MKO cells. (E) Quantification of fold change of area of spheroids. Error bars are standard error.