Table 2. Sizes and grades of tumor derived from hiPSCs transplanted into NOG mice.
hiPSC lines (passages) | No. | Tumor size (mm3) | Time after transplantation (wk) | Differentiation into germ layers | Grade of teratoma |
---|---|---|---|---|---|
201B7 (p35) | 1 | 1468 | 16 | Three germ layers | 3 |
2 | 1406 | 16 | Three germ layers | 1 | |
3 | 2026 | 14 | Three germ layers | 3 | |
4 | 648 | 16 | Three germ layers | 1 | |
5 | 991 | 16 | Ectoderm/mesoderm | 3 | |
6 | 332 | 16 | Three germ layers | 1 | |
253G1 (p46) | 1 | 760 | 16 | Three germ layers | 1 |
2 | 139 | 16 | Ectoderm/mesoderm | 1 | |
3 | 814 | 16 | Ectoderm/mesoderm | 1 | |
4 | 58 | 16 | Three germ layers | 1 | |
5 | 168 | 16 | Ectoderm/mesoderm | 1 | |
6 | 1599 | 13 | Ectoderm/mesoderm | 3 | |
409B2 (p38) | 3 | 244 | 16 | Ectoderm/mesoderm | 2 |
4 | 400 | 16 | Ectoderm/mesoderm | 3 | |
5 | 43 | 16 | Three germ layers | 1 | |
6 | 128 | 16 | Ectoderm/mesoderm | 1 | |
454E2 (p44) | 1 | 2369 | 15 | Three germ layers | 3 |
2 | 2030 | 11 | Three germ layers | 1 | |
3 | 804 | 16 | Ectoderm/mesoderm | 1 | |
4 | 1592 | 16 | Ectoderm/mesoderm | 1 | |
5 | 2319 | 15 | Three germ layers | 1 | |
6 | 2021 | 13 | Three germ layers | 1 | |
HiPS-RIKEN-1A (p24) | 1 | 697 | 16 | Three germ layers | 3 |
2 | 99 | 16 | Three germ layers | 1 | |
3 | 226 | 16 | Ectoderm/mesoderm | 3 | |
4 | 273 | 16 | Three germ layers | 2 | |
5 | 961 | 16 | Three germ layers | 1 | |
6 | 141 | 16 | Three germ layers | 1 | |
HiPS-RIKEN-2A (p27) | 6 | 1603 | 9 | Three germ layers | 2 |
HiPS-RIKEN-12A (p32) | 1 | 595 | 16 | Ectoderm/mesoderm | 1 |
2 | 85 | 16 | Three germ layers | 1 | |
5 | 506 | 16 | Three germ layers | 3 | |
6 | 49 | 16 | Three germ layers | 1 | |
ATCC-DYR0100 (unknown; >p11) | 1 | 2481 | 11 | Three germ layers | 3 |
2 | 1172 | 16 | Three germ layers | 1 | |
3 | 2030 | 8 | Three germ layers | 1 | |
4 | 690 | 16 | Three germ layers | 1 | |
6 | 2179 | 14 | Three germ layers | 1 | |
ATCC-HYR0103 (unknown; >p10) | 2 | 2380 | 11 | Three germ layers | 1 |
3 | 4218 | 13 | Three germ layers | 2 | |
4 | 2950 | 16 | Three germ layers | 2 | |
6 | 524 | 16 | Three germ layers | 1 | |
mc-iPS (unknown; >p27) | 2 | 181 | 16 | Three germ layers | 0 |
3 | 1921 | 15 | Three germ layers | 0 | |
5 | 1115 | 16 | Three germ layers | 3 | |
6 | 213 | 16 | Three germ layers | 1 |