Table 4. Genes having mutations, which were assessed as a high or moderate impact and confirmed in the COSMIC cancer database.

hiPSC lines	Genes having mutations reported in the COSMIC database
201B7	TNFRSF14, SPEN, NOTCH2, PIK3CA, TET2, FAT1, TERT, DROSHA, IL7R, APC, HLA-A*, NFKBIE, KMT2C, PCM1, NCOA2, OMD, NOTCH1, KAT6B, CREB3L1, MEN1, MAML2, ATM, KCNJ5, PTPRB, SH2B3, HNF1A, NCOR2, FLT3, ERCC5, FOXA1, HIF1A, ZFHX3, TP53, BRCA1, AXIN2, SETBP1, MAP2K2, JAK3, EP300, ZRSR2, FANCB
253G1	TNFRSF14, SPEN, NOTCH2, PIK3CA, TET2, FAT1, TERT, DROSHA, IL7R, APC, HLA-A, NFKBIE, CREB3L2, KMT2C, PCM1, NCOA2, OMD, NOTCH1, KAT6B, CREB3L1, MEN1, MAML2, ATM, KCNJ5, PTPRB, SH2B3, HNF1A, NCOR2, FLT3, ERCC5, FOXA1, HIF1A, ZFHX3, TP53, BRCA1, AXIN2, SETBP1, JAK3, EP300, AR, FANCB
409B2	TNFRSF14, SPEN, NOTCH2, PIK3CA, TET2, FAT1, TERT, DROSHA, IL7R, APC, HLA-A, NFKBIE, CREB3L2, KMT2C, PCM1, NCOA2, OMD, NOTCH1, KAT6B, CREB3L1, MEN1, MAML2, ATM, KCNJ5, PTPRB, SH2B3, HNF1A, NCOR2, FLT3, ERCC5, FOXA1, HIF1A, ZFHX3, TP53, BRCA1, AXIN2, SETBP1, JAK3, EP300, AR, FANCB
454E2	NOTCH2, ALK, AFF3, FANCD2, ATR, WWTR1, TET2, FAT4, FAT1, SDHA, IL6ST, APC, RANBP17, NSD1, NFKBIE, EGFR CREB3L2, EZH2, KMT2C, FANCG, NCOA4, KAT6B, FGFR2, CREB3L1, MEN1, MAML2, ATM, KCNJ5, ZNF384, SH2B3, HNF1A, NCOR2, ERCC5, FOXA1, ZFHX3, TP53, ERBB2, RNF43, RNF43, AXIN2, SETBP1, KDM6A, ATRX
HiPS-RIKEN-1A	SPEN, NOTCH2, ALK, FANCD2, FOXL2, KIT, KDR, PTPN13, TET2, FAT4, FAT1, SDHA, IL7R, APC, NSD1, HLA-A, NFKBIE, TRRAP, CREB3L2, KMT2C, NCOA2, CDKN2A, FANCG, PTCH1, KAT6B, FGFR2, CREB3L1, MEN1, MAML2, ATM, CBL, KCNJ5, ZNF384, SH2B3, HNF1A, NCOR2, FLT3, BRCA2, ERCC5, FOXA1, BLM, ZFHX3, ERBB2, RNF43, AXIN2, SETBP1, AR, ATRX
HiPS-RIKEN-2A	TNFRSF14, SPEN, NOTCH2, ALK, FANCD2, FOXL2, ATR, WWTR1, KDR, TET2, FAT4, FAT1, SDHA, APC, RANBP17, HLA-A, EGFR, CREB3L2, KMT2C, PTCH1, KAT6B, FGFR2, CREB3L1, MEN1, MAML2, ATM, KCNJ5, ZNF384, COL2A1, SH2B3, HNF1A, NCOR2, FLT3, BRCA2, ERCC5, FOXA1, ZFHX3, TP53, NF1, BRCA1, RNF43, AXIN2, SETBP1, TCF3, KDM6A, ATRX
HiPS-RIKEN-12A	TNFRSF14, NOTCH2, ALK, FANCD2, GATA2, ATR, WWTR1, KDR, PTPN13, TET2, FAT4, FAT1, APC, RANBP17, HLA-A, NFKBIE, EGFR, CREB3L2, KMT2C, PTCH1, RET, KAT6B, TCF7L2, CREB3L1, MEN1, MAML2, ATM, KCNJ5, ZNF384, COL2A1, SH2B3, HNF1A, NCOR2, POLE, FLT3, BRCA2, ERCC5, FOXA1, HIF1A, ZFHX3, TP53, RNF43, AXIN2, STK11, TCF3, ATRX
ATCC-DYR0100	TNFRSF14, NOTCH2, ALK, FANCD2, ATR, WWTR1, KDR, PTPN13, TET2, FAT1, DROSHA, IL7R, APC, NSD1, HLA-A, ELN, CREB3L2, KMT2C, KAT6B, CREB3L1, MEN1, MAML2, ATM, KCNJ5, CHD4, ZNF384, SH2B3, HNF1A, NCOR2, POLE, FLT3, ERCC5, FOXA1, ZFHX3, TP53, BRCA1, RNF43, SETBP1, ASXL1, MN1, EP300
ATCC-HYR0103	TNFRSF14, SPEN, NOTCH2, ALK, MSH2, KDR, FAT4, FAT1, IL7R, APC, KMT2C, NRG1, PDCD1LG2, OMD, TSC1, CREB3L1, MEN1, MAML2, ATM, KCNJ5, ZNF384, COL2A1, KMT2D, SH2B3, HNF1A, NCOR2, FLT3, FOXA1, ZFHX3, TP53, BRCA1, RNF43, AXIN2, MN1, EP300, AR, ATRX
mc-iPS	TNFRSF14, SPEN, NOTCH2, FANCD2, FOXL2, ATR, KIT, KDR, PTPN13, TET2, FAT4, FAT1, IL7R, APC, HLA-A, CREB3L2, KMT2C, PTCH1, NOTCH1, CREB3L1, MEN1, MAML2, ATM, KCNJ5, CHD4, ZNF384, SH2B3, HNF1A, NCOR2, FLT3, BRCA2, FOXA1, ZFHX3, TP53, RNF43, AXIN2, SETBP1, TCF3, JAK3, KDM6A, ATRX

*Variants of gene symbols indicated in bold letters were assessed as a “high” impact by SnpEff software.