Table 2. Parameters used in the cell-cycle module: Dimensionless values were marked in *.

Par	Description	Value	Refs
cell cycle module
k1	production rate of [CycB]	1.2 × 10−1 h−1	[70–72]
$k_2^{\prime }$	degradation rate of [CycB]	1.2 × 10−1 h−1	[70–72]
$k_2^{{}^{\prime \prime }}$	degradation rate of [CycB] by [Cdh1]	4.5 h−1	[70–72]
[p27/p21]	inhibition rate by [HIF1]	1.05 h−1	[70]
[CycB]th	threshold of [CycB] for cell division	1.0 × 10−1	[70–72]
$k_3^{\prime }$	activation rate of [Cdh1]	3.0 h−1	[70–72]
$k_3^{{}^{\prime \prime }}$	activation rate of [Cdh1] by [p55cdcA]	3 × 101 h−1	[70–72]
k4	inactivation rate of [Cdh1] by [CycB]	1.05 × 102 h−1	[70–72]
J3	Michaelis-Menton constant (activation)	*4.0 × 10−2	[70–72]
J4	Michaelis-Menton constant (inactivation)	*4.0 × 10−2	[70–72]
$k_5^{\prime }$	production rate of [p55cdcT]	1.5 × 10−2 h−1	[70–72]
$k_5^{{}^{\prime \prime }}$	transcription rate of [p55cdcT] by [CycB]	6.0 × 10−1 h−1	[70–72]
k6	degradation rate of [p55cdcT]	3.0 × 10−1 h−1	[70–72]
J5	dissociation constant of [p55cdcT]	*3.0 × 10−1	[70–72]
n	Hill coefficient	*4	[70–72]
k7	activation rate of [p55cdcA] by [Plk1]	3.0 h−1	[70–72]
k8	inactivation rate of [p55cdcA] by [Mad]	1.5 h−1	[70–72]
J7	Michaelis-Menton constant (activation)	*1.0 × 10−3	[70–72]
J8	Michaelis-Menton constant (inactivation)	*1.0 × 10−3	[70–72]
[Mad]	concentration of [Mad]	*1.0	[70–72]
k9	activation rate of [Plk1] by [CycB]	3.0 × 10−1 h−1	[70–72]
k10	degradation rate of [Plk1]	6.0 × 10−2 h−1	[70–72]
μ+	Growth rate parameter in [mass]	3.0 × 10−2 h−1	[71, 72]
m*	Growth rate parameter in [mass]	10	[71, 72]
ϵ	small parameter for μ	*6.0 × 10−3	[70–72]
miR-451-AMPK-mTOR-cell cycle (ODE)
ζ1	G0 switch parameter	*2.5	TW
n1	Hill-type parameter in G0 switch	*10	TW
Km	Hill-type parameter in G0 switch	*0.5	TW
ζ2	[HIF] switch parameter	*1.0	TW
n2	Hill-type parameter in [HIF] switch	*10	TW
KH	Hill-type parameter in [HIF] switch	*10.0	TW
$t{h}_G^{†}$	the threshold of glucose for [HIF] activation	*0.4	TW