Table 2. . Functional categories of genes recurrently mutated in acute myeloid leukemia.

Functional category	Genes
Signal transduction genes	FLT3, NRAS, KRAS, c-KIT, PTPN11
DNA modification genes	DNMT3, IDH1/2, TET2
Chromatin modifiers	MLL-fusions, ASXL1, EZH2, MLL-partial tandem duplication
Multi-function	NPM1
Chimeric or mutated transcription factors	PML/RARA, AML1/ETO, CBFB/MYH11, CEBPA, AML1
Tumor-suppressor genes	TP53, PHF6, WT1
Spliceosome genes	SF3B1, SRSF2, U2AF1
Cohesin complex genes	SMC1A, SMC3, RAD21, STAG2