Table 2.
Associations between oral anticoagulation and mortality. Odds ratios (ORs) and 95% confidence intervals (CIs) for 3 and 6 month all-cause mortality comparing the use of oral anticoagulants for the treatment of venous thromboembolism, OptumLabs Data Warehouse, 2012–2017.
| N | N all-cause deaths | OR (95% CI) for all-cause mortality | |||||
|---|---|---|---|---|---|---|---|
| 3 months | 6 months | ||||||
| 3 months | 6 months | Crude | IPTW MSM | Crude | IPTW MSM | ||
| DOAC vs warfarin comparisons | |||||||
| Warfarin | 35,704 | 802 | 1,208 | -- | -- | -- | -- |
| Rivaroxaban | 21,064 | 299 | 428 | 0.63 (0.55, 0.72) | 0.98 (0.83, 1.16) | 0.59 (0.53, 0.66) | 0.97 (0.84, 1.11) |
| Warfarin | 16,269 | 364 | 545 | -- | -- | -- | -- |
| Apixaban | 5,663 | 112 | 155 | 0.88 (0.71, 1.09) | 0.96 (0.74, 1.26) | 0.81 (0.68, 0.97) | 0.91 (0.72, 1.15) |
|
DOAC vs DOAC comparisons | |||||||
| Rivaroxaban | 14,630 | 202 | 278 | -- | -- | -- | -- |
| Apixaban | 5,663 | 112 | 155 | 1.44 (1.14, 1.82) | 1.05 (0.81, 1.37) | 1.45 (1.19, 1.77) | 1.07 (0.86, 1.34) |
DOAC: direct oral anticoagulant; IPTW MSM: inverse probability of treatment weighted marginal structural model IPTW weights were estimated using a logistic regression model for treatment, including the covariates age, age2, sex, census region, index date, index date2, diagnosis setting, the constituent Charlson and Elixhauser comorbidity and frailty variables, and concomitant medications.