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. 2018 Aug 24;109(10):3129–3138. doi: 10.1111/cas.13743

Figure 5.

Figure 5

Downregulation of Ambra1 increased sensitivity of breast cancer to epirubicin (EPI) in vivo. A, MDA‐MB‐231 cells were transfected with scrambled shRNA or 2450 for 48 h, and then the protein of Ambra1 was detected by western blotting. At the same time, the mRNA of AMBRA1 was tested by quantitative RT‐PCR (B). The results (mean ± SE) are from 3 independent experiments (*P < 0.05, **P > 0.05). C, After knocking down of Ambra1, MDA‐MB‐231 cells we inoculated BALB/c nude mice. Then, the mice were treated with 5 mg/kg EPI for indicated time, and the volume and weight of the tumor were measured (*P < 0.05)