Figure 1.

Effect of c‐Myc and SOX2 coexpression on cell invasion, migration, and vasculogenic mimicry (VM) formation in hepatocellular carcinoma (HCC) cells. A, Western blotting showed c‐Myc, SOX2, Nanog, CD133 and CD90 expression. HepG2‐c‐Myc‐SOX2 (HCS) cells successfully developed spheroid formation compared with HepG2 cells. B, HCS cells showed the highest rate of wound healing. C, Cell migration and invasion assays, VM formation by 3‐D culture and VE‐cadherin expression by immunofluorescence in c‐Myc or SOX2‐transfected HepG2 cells