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. 2018 Jul 23;12(5):378–386. doi: 10.4162/nrp.2018.12.5.378

Fig. 6. Effects of CF administration on AR expression in TP-induced BPH rats.

Fig. 6

(A) Representative photomicrographs of prostate tissues immunostained with an anti-AR are presented (magnification, 200X). Control, corn oil-injected and PBS-treated rats; BHP, TP (3 mg/kg)- and PBS-treated rats; CF-250, TP (3 mg/kg)- and CF (250 mg/kg)-treated rats; CF-500, TP (3 mg/kg)- and CF (500 mg/kg)-treated rats; CF-750, TP (3 mg/kg)- and CF (750 mg/kg)-treated rats; FINA, TP (3 mg/kg)- and finasteride (5 mg/kg)-treated rats. (B and C) The expression levels of AR, AR co-activators (ARA70 and SRC1) and PCNA were determined by Western blotting. The experiment was repeated three times among different experimental groups, and all the results were similar (B). Actin was used as an internal control. Values are mean ± SD of data from three separate experiments (P < 0.05) (C). BPH, benign prostatic hyperplasia; CF, Corni Fructus water extract; FINA, finasteride; DHT, dihydrotestosterone; AR, androgen receptor; ARA70, AR-associated protein 70; SRC1, steroid receptor coactivator-1; PCNA, proliferating cell nuclear antigen.