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. 2018 Jun 7;37(40):5451–5465. doi: 10.1038/s41388-018-0326-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Genes regulated by TFAP4 in MYCN-amplified neuroblastoma. Differentially expressed genes in MYCN-amplified neuroblastoma after silencing TFAP4. Forty hrs shRNA induction by doxycycline, total mRNA was collected from NGP and SK-N-DZ and analyzed by RNAseq. mRNA most significantly altered by shTFAP4 induction were shown (P < 0.001). a genes activated by TFAP4, b genes repressed by TFAP4. Relative expression of TFAP4-activated genes c and TFAP4 repressed genes d measured by qRT-PCR. Gene expression was measured by quantitative PCR 48 h after induction of shRNA against TFAP4. Mean ± std dev. Scatter plot and correlation analysis between TFAP4 VIPER activity and TFAP4-activated genes e and repressed genes f