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. 2018 Oct 4;8:14806. doi: 10.1038/s41598-018-33094-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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POU5F1P1 expression and mutation pattern compared to POU5F1P1 expression in normal tissue and each cancer tissue: (a) The fold-change of POU5F1P1 in various types of cancers was identified from our analyses shown in Supplementary Table S7 and expressed as the forest plot. (b–e) The box plot comparing specific POU5F1P1 expression in normal (left plot) and cancer tissue (right plot) was derived from the Oncomine database. The analysis was shown in seminoma relative to normal testicle (b), in renal carcinoma relative to normal renal (c), in melanoma relative to normal skin (d), and in breast relative to normal breast (e). (f) Significant hazard ratios in various types of cancers was identified from our analyses shown in Table S8 and expressed as a forest plot. (g-h) Survival curve comparing patients with high (red) and low (black, blue) expression in melanoma (g), breast (h) was plotted from OncoLnc and Kaplan Meier-plotter database. Survival curve was analyzed using a threshold Cox p-value < 0.05.