Table 2.
Brain regions showing a difference in BZD receptor binding potential (BP) of [11C] Flumazenil between PTSD subjects and healthy controls, and brain regions showing a significant positive correlation between BP and PTSD severity (CAPS score) in subjects with PTSD
| BP in brain region | x, y, z coordinates | T-value | Voxel p-value, uncorrected | Cluster size | Cluster p-value, corrected |
|---|---|---|---|---|---|
| PTSD > HC | |||||
| Superior & Caudal anterior cingulate cortex | 4, 4, 47 | 3.12 | 0.002 | 8429 | 0.002 |
| Precuneus | −1, −52, 42 | 3.03 | 0.003 | ||
| Precuneus | −6, −74, 22 | 3.30 | 0.001 | ||
| CAPS-BP correlation | |||||
| Left mid-insula | −32, −14, 8 | 3.68 | 0.002 | 618 | N.A. |
| Left anterior insula | −30, 10, 4 | 3.32 | 0.004 | ||
BP binding potential, BZD benzodiazepines, PTSD post-traumatic stress disorder, HC healthy controls, CAPS clinician-administered PTSD scale