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. 2018 Oct 4;8:14804. doi: 10.1038/s41598-018-32901-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of isoprenoid biosynthesis pathway. HMG-CoA, 3-hydroxy-3-methyl-glutaryl-CoA; MVA, mevalonic acid; MVA-5-P, mevalonic acid-5-phosphate; IPP, isopentenyl diphosphate; DMAPP, dimethylallyl diphosphate; FPP, farnesyl diphosphate; HMGS, 3-hydroxy-3-methylglutaryl-CoA synthase; HMGR1, hydroxy-3-methylglutaryl-CoA reductase 1; MVK, mevalonate kinase; SQS, squalene synthase; SQE, squalene epoxidase; βAS, β-amyrin synthase; CAS1, cycloartenol synthase 1; SSR2, sterol side chain reductase 2; SMT1, S-adenosyl-L-Met-dependent C-24 sterol methyltransferase 1. Solid and dashed arrows indicate single-step and multi-step reactions, respectively. Genes highlighted in grey represent those used in this study.