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. 2018 Sep 28;9:2249. doi: 10.3389/fmicb.2018.02249

FIGURE 4.

FIGURE 4

Sarconesin alignment and protein model. (A) Sarconesin multiple sequence alignment against selected proteins. (https://www.ncbi.nlm.nih.gov/): CDC42 cell division control protein 42 homologue OS = Bos taurus (Q2KJ93), CDC42_HUMAN Chain A, structure of the Rho family Gtp-binding protein Cdc42 in complex with the multifunctional regulator Rhogdi (gi| 7245832| 1DOA_A), CDC42_DROME Cdc42 homologue OS = Drosophila melanogaster GN = Cdc42 PE = 1 SV = 1 (P40793), Ras-related protein Rac1 [Lucilia cuprina] GenBank: KNC23156.1. Sarconesin has 100% sequence similarity with CDC proteins and 69% with Rac from L. cuprina. Translated sequences from L. sericata. Genome scaffold (JXPF01028806.1), transcriptomes ERR658157.22222021.1 and pupa SRR350018.17744834.1 genome scaffold (JRES01000256.1) and L. cuprina transcriptome SRR1853100.27006533.2. (B) Conserved domains found in JXPF01028806.1 L. sericata Blastp, showing Sarconesin a conserved residue from CDC42 domain. (C) Representative model of human CDC42 (PDB ID: 1DOA_A). Sarconesin is encrypted in a site between residues 111 and 123 (green), which folds as a β-sheet.