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. 2018 Sep 28;8:395. doi: 10.3389/fonc.2018.00395

Figure 1.

Figure 1

(A) (i) T2 weighted (ii) post-contrast T1 weighted and (iii) rCBV MR perfusion sequences of a lesion seen within the left temporal lobe. The lesion quotient is calculated using the ratio of the hypointense nodule on T2W imaging to the total enhancing area on T1W imaging. This case showed a lesion quotient of 0.71 and increased rCBV is suggestive of tumor recurrence. (B) (i) rCBV and (ii) post-contrast T1 weighted sequences showing increased blood flow within the periphery of the lesion. This was a tumor recurrence proven by histopathology. (iii) rCBV and (iv) post-contrast T1W sequences of another patient showing no increased blood flow within the periphery in keeping with radiation necrosis. (C) (i, ii) MR spectroscopy and (iii) post-contrast T1 weighted sequences of a growing pericallosal lesion post-WBRT. (i) typical high lipid-lactate peak seen in radiation necrosis at the right cingulum while (ii) shows increased Cho:Cr and Cho:NAA ratios suggestive of tumor recurrence over the left cingulum. (D) (i) F-18 FET PET showing intense amino acid tracer uptake within the enhancing lesion seen in (ii) post-contrast T1 weighted sequence. This is suggestive of tumor recurrence and found to be recurrent RCC metastasis on histology.