Table 3.
Open-label studies.
| Participants' characteristics | Baclofen treatment | Clinical effects of baclofen treatment | ||||||
|---|---|---|---|---|---|---|---|---|
| References | Gender | Notes and comorbidities | Basal DDD | Mean daily dose | Weeks | Alcohol | Anxiety | Depression |
| (42) | 10 M | - | ~8 | 30 mg | 4 | ↓ | – | – |
| (43) | 60 N/A | Article in French | - | 145 mg | 12 | ↓ | – | – |
| (44) | 75 M; 25 F | 65 participants suffered from cirrhosis | ~7 | 40 mg | 52 | ↓ | – | – |
| (45) | 9 M; 3 F | 5 participants suffered from other psychiatric disorders Anxiety levels: BAI = ~5 Depression levels: BDI = ~8 |
~8 | 30 mg | 12 | ↓ | ↓ | ↔ |
| (46) | 80 M (vs. 75 M benfothiamine) | Participants with other psychiatric disorders were excluded Anxiety levels: HAM-A = ~20 Depression levels: HAM-D = 12 |
- | 50 mg | 12 | ↓ | ↓ | ↔ |
| (47) | 10 M; 6 F | Participants with other psychiatric disorders were excluded Anxiety levels: STAI = ~51 Depression levels: ZUNG = 41 |
- | 30 mg | 12 | ↓ | ↓ | ↔ |
BAI, Beck Anxiety Inventory (cut off ≥ 10); BDI, Beck's Depression Inventory (cut off > 10); DDD, Drinks per Drinking Day (1 drink = ~12 g of pure alcohol); F, Female; HAM-A, Hamilton Anxiety Rating Scale (cut off > 17); HAM-D, Hamilton Depression Rating Scale (cut off ≥ 8); M, Male; N/A, Not Available; STAI, Spielberger State Trait Anxiety Inventory (cut off ≥ 40); ZUNG, Self-rating depression scale (cut off ≥ 50).