Table 4.

Human laboratory studies.

	Participants' characteristics			Baclofen Treatment		Clinical Effects of Baclofen Treatment
References	Gender	Notes on comorbidity	Baseline DDD	Mean daily dose	Weeks	Alcohol	Anxiety	Depression
(26)	14 M; 4 F vs. 13 M; 3 F placebo	Anxiety levels: STAI = ~47	~8	30 mg	1	↔	↔	N/A
(48)	10 M; 4 F	Participants with other psychiatric disorders were excluded	~8	30 mg	1	↔	Baseline anxiety levels did not modulate alcohol drinking

DDD, Drinks per Drinking Day (1 drink = 12 g of pure alcohol); F, Female; M, Male;N/A, Not Available; STAI, Spielberger State Trait Anxiety Inventory (cut off ≥ 40).