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. 2018 Sep 4;18(5):4381–4387. doi: 10.3892/mmr.2018.9452

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Dicer expression levels are decreased in A2780/DDP cells. (A) Western blots presenting the Dicer protein levels in A2780 cells following treatment with 20 µM cisplatin for 0, 12 and 24 h. (B) Cell survival following cisplatin treatment was significantly higher in A2780/DDP cells when compared with A2780 cells, as determined by MTT assays. (C) The cisplatin IC₅₀ was significantly increased in A2780/DDP cells when compared with that in A2780 cells following the MTT assays. (D) The relative level of Dicer mRNA was decreased in A2780/DDP cells when compared with A2780 cells, as determined by reverse transcription-quantitative polymerase chain reaction. Dicer expression was normalized to β-actin. (E) Dicer protein expression was downregulated in A2780/DDP cells when compared with A2780 cells according to western blot analyses. *P<0.05, **P<0.01 and ***P<0.001, vs. A2780/as indicated.