Table I.
GO enrichment analysis and functional annotation of DEGs.
| A, Upregulated | |||||
|---|---|---|---|---|---|
| Category | Term | Description | Count | % | P-value |
| GOTERM_BP_FAT | GO:0007155 | Cell adhesion | 25 | 11.1 | 7.08×10−6 |
| GOTERM_BP_FAT | GO:0022610 | Biological adhesion | 25 | 11.1 | 7.26×10−6 |
| GOTERM_BP_FAT | GO:0050808 | Synapse organization | 7 | 3.1 | 1.13×10−4 |
| GOTERM_BP_FAT | GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | 12 | 5.3 | 1.24×10−4 |
| GOTERM_BP_FAT | GO:0007267 | Cell-cell signaling | 19 | 8.4 | 5.50×10−4 |
| GOTERM_CC_FAT | GO:0044459 | Plasma membrane part | 55 | 24.4 | 7.52×10−6 |
| GOTERM_CC_FAT | GO:0045202 | Synapse | 18 | 8.0 | 8.07×10−6 |
| GOTERM_CC_FAT | GO:0005887 | Integral to plasma membrane | 35 | 15.6 | 2.90×10−5 |
| GOTERM_CC_FAT | GO:0030054 | Cell junction | 21 | 9.3 | 3.00×10−5 |
| GOTERM_CC_FAT | GO:0031226 | Intrinsic to plasma membrane | 35 | 15.6 | 4.59×10−5 |
| GOTERM_MF_FAT | GO:0004714 | Transmembrane receptor protein tyrosine kinase activity | 6 | 2. 7 | 1.36×10−3 |
| GOTERM_MF_FAT | GO:0005509 | Calcium ion binding | 22 | 9.8 | 4.10×10−3 |
| GOTERM_MF_FAT | GO:0022843 | Voltage-gated cation channel activity | 7 | 3.1 | 9.44×10−3 |
| GOTERM_MF_FAT | GO:0022836 | Gated channel activity | 10 | 4.4 | 1.41×10−2 |
| GOTERM_MF_FAT | GO:0008083 | Growth factor activity | 7 | 3.1 | 1.43×10−2 |
| B, Downregulated | |||||
| GOTERM_BP_FAT | GO:0016125 | Sterol metabolic process | 6 | 2.2 | 1.22×10−2 |
| GOTERM_BP_FAT | GO:0006954 | Inflammatory response | 11 | 4.1 | 1.34×10−2 |
| GOTERM_BP_FAT | GO:0007229 | Integrin-mediated signaling pathway | 5 | 1.9 | 1.51×10−2 |
| GOTERM_BP_FAT | GO:0006631 | Fatty acid metabolic process | 8 | 3.0 | 1.87×10−2 |
| GOTERM_BP_FAT | GO:0007264 | Small GTPase mediated signal transduction | 10 | 3.7 | 2.38×10−2 |
| GOTERM_CC_FAT | GO:0009898 | Internal side of plasma membrane | 12 | 4.5 | 4.55×10−2 |
| GOTERM_CC_FAT | GO:0005811 | Lipid particle | 3 | 1.1 | 1.78×10−2 |
| GOTERM_CC_FAT | GO:0044459 | Plasma membrane part | 42 | 15.7 | 2.57×10−2 |
| GOTERM_CC_FAT | GO:0005739 | Mitochondrion | 24 | 9.0 | 2.68×10−2 |
| GOTERM_CC_FAT | GO:0031090 | Organelle membrane | 24 | 9.0 | 2.91×10−2 |
| GOTERM_MF_FAT | GO:0030695 | GTPase regulator activity | 14 | 5.2 | 3.60×10−3 |
| GOTERM_MF_FAT | GO:0060589 | Nucleoside-triphosphatase regulator activity | 14 | 5.2 | 4.34×10−3 |
| GOTERM_MF_FAT | GO:0005509 | Calcium ion binding | 23 | 8.6 | 6.95×10−3 |
| GOTERM_MF_FAT | GO:0005178 | Integrin binding | 5 | 1.9 | 8.49×10−3 |
| GOTERM_MF_FAT | GO:0005096 | GTPase activator activity | 8 | 3.0 | 3.12×10−2 |
Count indicates the enriched gene number in the category. GO, gene ontology; DEGs, differentially expressed genes BP, biological process; CC, cellular component; MF, molecular function.