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. 2018 Sep 14;18(5):4428–4438. doi: 10.3892/mmr.2018.9485

Figure 6.

Figure 6.

FKBP11 protects HT-29 cells against IFN-γ/TNF-α induced apoptosis by inhibiting the JNK/caspase signaling pathway. (A) Cellular apoptosis and (B) western blot analyses of p-JNK and caspase-12 following post-treatment with IFN-γ/TNF-α and overexpression of FKBP11 in HT-29 cells. Bar graphs present the quantitative analysis of apoptosis rates and the densities of p-JNK, JNK and caspase-12 proteins vs. GAPDH. Data are presented as mean ± standard error of the mean (n=3). #P<0.05 vs. IFN-γ/TNF-α untreated control; *P<0.05 vs. IFN-γ/TNF-α treated control. PI, propidium iodide; IFN-γ, interferon-γ; TNF-α, tumor necrosis factor-α; HA, hemagglutinin; FKBP11, FK506 binding protein 11; JNK, c-Jun N-terminal kinase; p-, phospho-.