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. 2018 Sep 13;18(5):4289–4296. doi: 10.3892/mmr.2018.9482

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Copyright: © Hu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — SC protects HT22 cells against L-Glu-induced damage. (A) Chemical structure of SC. HT22 cells were pre-incubated with 5 and 15 µM SC for 3 h, and then exposed to L-Glu for another 24 h. (B) SC enhanced cell viability as measured by MTT assay. (C) SC suppressed LDH release as measured using an In vitro Toxicology Assay kit. (D) SC decreased caspase-3 activation. (E) Flow cytometric analysis revealed that SC reduced apoptosis. Data are expressed the as the mean ± standard deviation (n=6). ^###P<0.001 vs. CTRL; *P<0.05, **P<0.01, ***P<0.001 vs. L-Glu. AV, Annexin V; CTRL, control; LDH, lactate dehydrogenase; L-Glu, L-glutamic acid; PI, propidium iodide; SC, scutellarin.