Table 4.
Catalog of previously published mutations from linezolid-resistant clinical isolates.
|
Mutation |
Note | MIC value (µg/ml) | Refs. | |
|---|---|---|---|---|
| rrl | rplC | |||
| WT | – | No mutations in rplD, rplV, whiB7, rrl, erm-37 | 8 (3 strains) | [23] |
| WT | 4 (1 strain) | |||
| – | T460C | 2 resistant, 3 acquired resistance during treatment | 4–16 | [24] |
| G2447T | – | acquired resistance during treatment | 16 | |
| – | T460C | – | 2 | [28] |
| – | T460C | 0.5 | ||
| – | T460C | 4 | ||
| G2576T | – | 4 | ||
| G2576T | – | 4 | ||
| – | T460C | 8 isolates | – | [19] |
| G2814T | – | 1 isolate | ||
| C1921T | – | 1 isolate | ||
| G2294A | – | 1 isolate acquired resistance during treatment | ||
| G2576T | – | 1 MDR-TB isolate | 4 | [13] |
| A2572C | – | |||
| – | T460C | 2 XDR-TB isolates | 4–16 | [12] |
Mutations described in rrl and rplC genes. A dash (–) is used to indicate where data was not available. WT- wild type, no variants detected.