Table 5.

Mutation frequencies and selection concentrations for bedaquiline-, clofazimine- and linezolid-resistant spontaneous mutants from previously published studies.

Drug	Conc (µg/ml)	Strain	Mutation frequency	Refs.
Bedaquiline	0.12	Fully susceptible M. tuberculosis	5 × 10–7	[8]
	0.12	M. smegmatis	2 × 10–8
	0.24	Fully susceptible M. tuberculosis	5 × 10–8
	0.24	M. smegmatis	1 × 10–8
	0.03-0.05	Fully susceptible M. tuberculosis	1 × 10–8	[11]
		Clinical M. tuberculosis	5 × 10–8
		Clinical M. tuberculosis	1 × 10–8
		Clinical M. tuberculosis	1 × 10–8
	0.015-0.5	Clinical strain M. fortuitum	1.5 × 10–8
	0.25-8	Clinical strain M. abscessus	1.5 × 10–8
	1	Fully susceptible M. tuberculosis	6 × 10–9	[1]
		Pyrazinamide-resistant M. tuberculosis	4 × 10−7
Clofazimine	0.25	Fully susceptible M. tuberculosis	5 × 10−6	[10]
	1	Fully susceptible M. tuberculosis	5 × 10−5	[1]
		Pyrazinamide-resistant M. tuberculosis	7 × 10−7
Linezolid	–	Fully susceptible M. tuberculosis	2 × 10−8	[23]
	–	Fully susceptible M. tuberculosis	5 × 10−9
	2	Fully susceptible M. tuberculosis	1 × 10−8	[1]
		Pyrazinamide-resistant M. tuberculosis	1 × 10−7

A dash (–) is used to indicate where data was not available.