Figure 2. A highly connected web of palmitoylation events.

(A) ER‐resident ZDHHC6 can autopalmitoylate, like other DHHC family members. In addition, three cysteine residues within the C‐terminal tail of ZDHHC6 are palmitoylated by a distinct enzyme, ZDHHC16, representing a palmitoylation cascade. (B) The acylprotein thioesterase APT2, which itself requires palmitoylation to function normally, can remove the C‐terminal palmitoyl groups on ZDHHC6.