Table 1. Clinical data and types of oculomotor dysfunction of the amyotrophic lateral sclerosis subjects.
| Pts | Sex/age (y)/disease duration (m) | Onset pattern/Awaji criteria | SWJ | Smooth pursuit | Saccadic accuracy | HSN | Positional nystagmus | Drug* |
|---|---|---|---|---|---|---|---|---|
| B1 | M/72/21 | B/definite | - | 0.2 and 0.4 Hz abnormal | Hypometria | + | - | |
| B2 | F/66/32 | B/probable | - | 0.1, 0.2, and 0.4 Hz abnormal | Hypometria | - | n.c. | |
| B3 | F/76/14 | B/definite | - | 0.1, 0.2, and 0.4 Hz abnormal | Hypometria | - | - | |
| B4 | F/49/48 | BC/probable | - | 0.1, 0.2, and 0.4 Hz abnormal | Hypometria | + | - | + |
| B5 | M/63/12 | BC/definite | - | 0.2 and 0.4 Hz abnormal | Hypometria | + | - | |
| B6 | F/66/7 | B/definite | - | 0.1, 0.2, and 0.4 Hz abnormal | Hypometria | + | - | |
| B7 | F/67/14 | B/definite | - | Normal | Normal | - | - | |
| B8 | M/62/11 | B/definite | - | 0.1, 0.2, and 0.4 Hz abnormal | Hypometria | + | + | + |
| B9 | F/38/6 | B/possible | - | 0.1, 0.2, and 0.4 Hz abnormal | Normal | + | + | + |
| B10 | M/63/15 | B/definite | + | 0.1, 0.2, and 0.4 Hz abnormal | Normal | + | + | |
| S1† | M/60/15 | C/definite | - | 0.1, 0.2, and 0.4 Hz abnormal | Hypometria | - | n.c. | + |
| S2 | M/52/19 | C/definite | - | 0.2 and 0.4 Hz abnormal | Normal | - | - | + |
| S3 | M/31/42 | C/definite | + | 0.1, 0.2, and 0.4 Hz abnormal | Hypermetria | + | - | + |
| S4 | M/49/8 | C/definite | - | Normal | Normal | + | n.c. | + |
| S5 | M/61/9 | C/definite | - | Normal | Normal | + | n.c. | |
| S6 | F/53/17 | C/possible | - | 0.1, 0.2, and 0.4 Hz abnormal | Hypometria | - | n.c. | |
| S7 | M/65/6 | C/definite | - | 0.1, 0.2, and 0.4 Hz abnormal | Normal | - | n.c. | |
| S8 | F/47/9 | L/definite | - | Normal | Normal | - | n.c. | |
| S9 | F/40/8 | L/definite | - | Normal | Normal | - | - | |
| S10 | M/60/25 | CL/definite | - | Normal | Normal | + | + | |
| S11 | M/55/14 | C/possible | - | Normal | Normal | - | + | + |
| S12 | F/48/9 | C/definite | - | Normal | Normal | + | + | |
| S13 | F/62/8 | CL/definite | + | 0.1, 0.2, and 0.4 Hz abnormal | Rt hypometria | + | - | + |
| S14 | M/54/5 | L/definite | - | Normal | Normal | - | - | + |
| S15 | M/72/25 | C/definite | + | Normal | Rt hypermetria | + | - | + |
| S16 | M/58/40 | L/definite | - | 0.2 and 0.4 Hz abnormal | Normal | - | - | |
| S17 | F/67/37 | C/probable | + | 0.1, 0.2, and 0.4 Hz abnormal | Hypometria | - | - | + |
| S18 | M/53/13 | L/definite | - | Normal | Normal | - | + | |
| S19 | M/55/13 | C/definite | + | 0.1, 0.2, and 0.4 Hz abnormal | Normal | - | - | |
| S20 | M/46/10 | C/definite | - | Normal | Normal | + | + | + |
| S21 | F/67/6 | L/probable | - | Normal | Normal | + | - | + |
| S22 | M/58/17 | C/possible | + | Normal | Normal | + | - | + |
*Small doses of benzodiazepine and/or baclofen, †With parkinsonism.
B: bulbar, B1–B10: bulbar-onset group, C: cervical, HSN: head-shaking nystagmus, L: lumbosacral, m: months, n.c.: not checked, Pts: patients, Rt: right, S1–S22: spinal-onset group, SWJ: square-wave jerks, y: years.