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ET-1, ERA, and NOX4 levels were increased in the lung tissue of monocrotaline (MCT)- induced pulmonary arterial hypertension (PAH) rats. (A) ET-1, (B) ERA, and (C) NOX4 levels significantly increased in the lung tissue 4 weeks after MCT injection. *P<0.05 significantly different between C and M groups. ET-1, endothelin-1; ERA, endothelin receptor A; NOX4, NADPH oxidase 4; Gapdh, glyceraldehyde 3-phosphate dehydrogenase; C, control group; M, MCT group.
