Fig. 3.
Changes in fractional Na+ reabsorption (ΔFNa) along the proximal tubule of the male rat, when individual parameters are set to female rat values. The lower single-nephron glomerular filtration rate (SNGFR) in the female increases ΔFNa because of the lower filtered load, even though absolute Na+ reabsorption decreases. AQP1, aquaporin-1; Cldn2, claudin-2; NaPi2, Na+-phosphate cotransporter 2; NHE3, Na+/H+ exchanger isoform 3; SGLT2, Na+-glucose cotransporter 2.