Table 1.
Key parameter differences between male and female rat proximal tubule models
| Parameter | Female-Male Ratio | References |
|---|---|---|
| SNGFR | 0.8 | (3, 24, 26) |
| Proximal tubule length | 0.8 | (3, 27, 31) |
| Proximal tubule diameter | 0.8 | (3, 27, 31) |
| NHE3 activity | 0.83 | (35) |
| NaPi2 | 0.75 | (35) |
| SGLT2 | 2.5 | (28) |
| PNa (paracellular) | 0.4 | (35) |
| PCl (paracellular) | 0.4 | (35) |
| Pf (transcellular) | 0.64 | (35) |
NaPi2, Na+-phosphate cotransporter 2; NHE3, Na+/H+ exchanger isoform 3; PNa, Na+ permeability; PCl, Cl− permeability; Pf, water permeability; SGLT2, Na+-glucose cotransporter 2; SNGFR, single-nephron glomerular filtration rate.