Fig. 1.

NM922 prevents the conversion of normal human lung fibroblasts to the transforming growth factor-β (TGF-β)-induced myofibroblast phenotype in vitro. A: chemical structure of NM922. B and C: representative blots of phosphorylated (p-)focal adhesion kinase (FAK), cyclooxygenase-2 (COX-2), α-smooth muscle actin (α-SMA), cyclin D3, and p-4E-binding protein 1 (4E-BP1) (B) and p-STAT3, p-p70S6 kinase (p70S6K), and p-Akt (C). D: relative fold changes in the intensity of blots for α-SMA, p-FAK, p-Akt, p-P70S6K, p-STAT3, p-4E-BP1, cyclin D, and COX-2 in the TGF-β + vehicle (Veh)-treated group. Numbers inside columns denote sample sizes. NS, not significant.