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Pressure-overload heart failure experimental protocol and survival rate. A: mice were subjected to transverse aortic constriction (TAC) surgery. NM922 or vehicle treatment was administered daily via intraperitoneal injection starting 6 wk after TAC and continued for 10 wk until the 16-wk end point. B: percent survival over the course of the study revealed that administration of NM922 resulted in 87% survival compared with 64% survival in vehicle-treated mice. LV, left ventricular.
