Fig. 5.

NM922 attenuates transverse aortic constriction (TAC)-induced myocardial collagen deposition and fibrosis. A: representative images of cardiac tissue from vehicle- and NM922-treated animals at 16 wk after TAC stained for picrosirius red for fibrosis. B: quantification of the percent collagen volume fraction (CVF). C–F: mRNA levels of collagen type I (C), collagen type III (D), TNF-α (E), and lysyl oxidase (LOX; F) were measured in ventricular homogenates from mice treated with NM922 or vehicle at 16 wk after TAC. Numbers inside bars denote numbers of animals/group.