Fig. 1.

Lysyl oxidase (LOX) inhibition prevented volume overload (VO)-induced increases in wall stress. Animals were divided into the following four groups: sham surgery (sham group), VO surgery (VO) group, sham + LOX inhibitor (β-aminopropionitrile; sham + B group), and VO + LOX inhibitor (VO + B group). VO caused an increase in the end-diastolic volume (EDV)-to-LV mass ratio, indicative of increased stress, and LOX inhibition completely prevented this increase (A). The equation in the LOX inhibition attenuated VO-induced cardiac wall stress section was used to calculate diastolic wall stress (B) and systolic wall stress (C). VO led to an increase in both diastolic and systolic wall stresses, which were both attenuated by the LOX inhibitor. n = 4–8 animals/group. Statistical significance is denoted as follows: *P < 0.05 vs. the sham group and †P < 0.05 vs. the VO group.