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. Author manuscript; available in PMC: 2019 Jan 12.
Published in final edited form as: N Engl J Med. 2018 Jun 3;379(2):111–121. doi: 10.1056/NEJMoa1804710

Table 2.

Estimated Survival Rates According to Recurrence Score and Assigned Treatment in the Intention-to-Treat Population.*

End Point and Treatment Group Rate at 5 Yr Rate at 9 Yr
percent
Invasive disease-free survival--
    Score of ≤10, endocrine therapy 94.0±0.6 84.0±1.3
     Score of 11–25, endocrine therapy 92.8±0.5 83.3 ±0.9
     Score of 11–25, chemoendocrine therapy 93.1±0.5 84.3±0.8
     Score of ≥26, chemoendocrine therapy 87.6±1.0 75.7±2.2
Freedom from recurrence of breast cancer at a distant site
     Score of ≤ lO, endocrine therapy 99.3±0.2 96.8±0.7
     Score of 11–25, endocrine therapy 98.0±0.3 94.5±0.5
     Score of 11–25, chemoendocrine therapy 98.2±0.2 95.0±0.5
     Score of ≥ 26, chemoendocrine therapy 93.0±0.8 86.8±1.7
Freedom from recurrence of breast cancer at a distant or local-regional site
     Score of ≤ 10, endocrine therapy 98.8±0.3 95.0±0.8
     Score of 11–25, endocrine therapy 96.9±0.3 92.2±0.6
     Score of 11–25, chemoendocrine therapy 97.0±0.3 92.9±0.6
     Score of ≥ 26, chemoendocrine therapy 91.0±0.8 84.8±1.7
Overall survival
     Score of ≤ lO, endocrine therapy 98.0±0.4 93.7±0.8
     Score of 11–25, endocrine therapy 98.0±0.2 93.9±0.5
     Score of 11–25, chemoendocrine therapy 98.1±0.2 93.8±0.5
     Score of ≥ 26, chemoendocrine therapy 95.9±0.6 89.3±1.4
*

Plus–minus values are Kaplan–Meier estimates ±SE.

Invasive disease–free survival was defined as freedom from invasive disease recurrence, second primary cancer, or death.