Table 1.
Measured and modeled kinetic constants for perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in large rainbow trout
| Ng and Hungerbuehler [32]1, adjusted2 | ||||
|---|---|---|---|---|
| Consoer et al. [129] PFOA mean (SD) |
Consoer et al. [130] PFOS mean (SD) |
PFOA med3 (range) | PFOS med3 (range) | |
| k1 (L/kg/d) | 0.19 (0.09) | 0.85 (0.29) | 0.126 (0.03 – 0.46) | 1.75 (0.19 – 2.43) |
| k2 (1/d) | 0.030 (0.011) | 0.027 (0.010) | 0.010 (0.0085 – 0.014) | 0.014 (0.014 – 0.092) |
| kR (1/d) | 0.330 (0.236) | 0.007 (0.003) | 0.25 (0.024 – 0.33) | 0.023 (0.023 – 0.33) |
| T1/24 | 12.6 (7.2) | 86.9 (14.1) | 2.67 (2.02 – 43.3) | 68.7 (2.01 – 184) |
Abbreviations: k1 – gill uptake rate constant; k2 – gill (branchial) elimination rate constant; kR – renal elimination rate constant; T1/2 – whole-body elimination half-life.
1
Model parameterized for a 1.1 kg rainbow trout using the urine flow rate (UFR) given by Consoer et al.[129]
2
Adjusted by reducing gill permeability by a factor of 15.
3
Model predictions obtained using median (med), maximum and minimum reported values for equilibrium association constants with albumin (KA).