Table 2.
Dysregulated lncRNAs in neurodegenerative diseases.
| lncRNAs | Direction of change | Relative disease | Biological function | References |
|---|---|---|---|---|
| Sox2OT | Up | AD, PD | Regulate cotranscribed Sox2 gene expression to down neurogenesis. | Arisi et al., 2011; Shimozaki, 2014 |
| BC200 | up(Soma) down(Dentritic) | AD, PD | Modulate local proteins in postsynaptic dendritic micro-domains to maintenance of long-term synaptic plasticity. | Lukiw et al., 1992; Mus et al., 2007; Vucićević et al., 2014; Luo and Chen, 2016 |
| BACE1-AS | up | AD | Increase BACE1 mRNA stability resulting in additional Aβ42 generation through a post-transcriptional feed-forward mechanism. | Faghihi et al., 2008; Liu et al., 2014 |
| NAT-Rad18 | up | AD | Down the expression of DNA repair protein Rad18 resulting in the neuron being more sensitive to apoptosis. | Parenti et al., 2007 |
| NDM29 | up | AD | Promotes Aβ secretion with increased Aβ42/ Aβ40 ratio, expression induced by inflammatory processes. | Massone et al., 2012 |
| 51A | up | AD | Promotes the alternative splicing of SORL1 and increases Aβ formation. | Ciarlo et al., 2013; Tan et al., 2013; Luo and Chen, 2016 |
| 17A | up | AD | Impair GABAB signaling pathway by decreasing GABAB R2 transcription. | Massone et al., 2011 |
| GDNFOS | Dysregulated/differences in tissue expression patterns | AD | Modulate the expression of endogenous GDNF in human brain. | Airavaara et al., 2011 |
| naPINK1 | up | PD | Stabilize the svPINK1, resulting in disturbed mitochondrial respiratory chain, and then increase the sensitivity to apoptosis. | Chiba et al., 2009; Sai et al., 2012 |
| PINK1-AS | - | PD | Positively regulates the stability of svPINK1 transcript. | Scheele et al., 2007 |
| UCHL1-AS | - | PD | Positively regulates UCHL1 mRNA translation. | Carrieri et al., 2012, 2015 |
| HAR1 | down | HD | Necessary for retinal development, the function with HD not be mentioned. | Johnson et al., 2010; Johnson, 2012 |
| HTT-AS | down | HD | HTTAS-v1 specifically reduces endogenous HTT transcript levels. | Chung et al., 2011 |
| MEG3 | down | HD | Binds the PCR2 epigenetic silencing complex. | Johnson, 2012 |
AD, Alzheimer's disease; PD, Parkinson's disease; HD, Huntington's disease; Sox2OT, Sox2 overlapping transcript; BACE1-AS, β-site amyloid precursor protein cleaving enzyme 1 antisense; GDNFOS, glial cell derived neurotrophic factor opposite strand; HAR1, human accelerated region 1; HTT-AS, Huntingtin antisense; PINK1-AS, PTEN induced putative kinase 1 antisense; UCHL1-AS, ubiquitin C-terminal hydrolase L1 antisense; MEG3, maternally expressed 3; NDM29, Neuroblastoma Differentiation Marker 29.