Fig. 4.

Performance of strict filtering, bamcmp, Xenome and XenofilteR on in silico mixed samples. a. Schematic overview of samples, dilutions and sequence read type for generation of the samples mixed in silico. b. Percentages of sequence reads remaining per species after filtering with strict filtering, bamcmp, Xenome and XenofilteR options for the 50:50, mouse (BALB/Cj):human (NA12878) WGS mixes. c. Variant Allele Frequency (VAF) of the SNVs in the original sample compared to unfiltered and filtered samples after in silico-mixing with mouse sequence reads. d. Venn diagrams of non-synonymous mutations in the original sample with filtered and unfiltered samples