Fig. 3.

Comparative analysis of gene body and repeat methylation patterns from different developmental stages, tissues and animals. a Comparative analysis of gene body methylation patterns. The heatmap shows average gene body methylation levels in eight independent samples (columns). Methylation levels are indicated on a scale from 0 (blue) to 1 (red). Only genes with sufficient coverage in all eight samples are shown. E1.7: stage 1.7 embryos, hep.: hepatopancreas, musc.: abdominal musculature, hemo: hemocytes. Colors denote individual animals. b Parallel analysis of housekeeping genes. c Methylation of the most frequent repeat classes. LINEs (long interspersed nuclear elements): N = 25,622, SINEs (short interspersed nuclear elements): N = 14,821, DNAs (DNA transposons): N = 7144, LTRs (long terminal repeats): N = 6483, simple (simple repeats): N = 3889. d Location-dependent methylation of repeats