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. 2018 Oct 4;16:273. doi: 10.1186/s12967-018-1638-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The combined prognostic role of the systemic immune-inflammation index and tumor-infiltrating lymphocytes. Estimated Kaplan–Meier curves for overall survival grouped according systemic immune-inflammation index (SII) and tumor-infiltrating lymphocytes (TILs) category. a Patients grouped according to TILs level at the invasive margin and SII; The 5-year overall survival were: low SII and high TILs: 60%; high SII and high TILs: 44%; low SII and low TILs: 37%; high SII and low TILs: 20%. b Patients grouped according to TILs level in the tumor’s central region and SII; low SII and high TILs: 49%; high SII and high TILs: 33%; low SII and low TILs: 33%; high SII and low TILs: 21%