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. 2018 Sep 8;5(10):ofy221. doi: 10.1093/ofid/ofy221

Figure 1.  .

Figure 1. 

Impact of T97A mutation on phenotypic sensitivity to dolutegravir in HIV-1 isolates with baseline partial sensitivity to dolutegravir. (A) Participant #1 pre-T97A (Mutations – G140S, Q148H; DTG FC 4.61); (B) participant #1 post-T97A (Mutations – G140S, Q148H, T97A; DTG FC 66); (C) participant #2 pre-T97A (Mutations – G140S, Q148H, E138T; DTG FC 6.71); (D) participant #2 post-T97A (Mutations – G140S, Q148H, E138T, T97A; DTG FC 119). HIV-1 phenotypic inhibition curves were obtained from PhenoSense™ Integrase and PhenoSense GT™ plus Integrase (Courtesy of Monogram Biosciences, South San Francisco, CA).