A) Serum human insulin and B) Blood glucose levels of rats in treated with (▴) Insulin alone, (■) Zinc-insulin, (●) Chitosan-zinc-insulin complex loaded thermosensitive polymeric delivery systems, (×) Streptozotocin control, and (♦) Untreated control; (insulin loading; 30 IU/kg) [n=6, mean ± SD, *: significantly different than insulin alone, and #: significantly different than zinc-insulin at P<0.05]