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. Author manuscript; available in PMC: 2018 Oct 5.
Published in final edited form as: J Control Release. 2012 Aug 7;163(2):145–153. doi: 10.1016/j.jconrel.2012.07.035

Table 1:

In vivo pharmacokinetic parameters of insulin in rats

Treatment Groups Insulin dose
(IU/kg)		 AUC(0-t)
(μU.day/ml)		 Fold increase in
AUC compared
to insulin alone		 Fold increase in AUC
compared to zinc-
insulin
Insulin alone 30 1481.36±105.6 --- ---
Zinc-insulin 30 1886.68±92.2 1.27 ---
Chitosan-zinc-insulin 30 2733.08±103.8 1.85 1.5
Insulin alone 45 1686.79±93.8 --- ---
Zinc-insulin 45 2073.58±110.1 1.23 ---
Chitosan-zinc-insulin 45 3458.79±153.3 2.1 1.3

[Mean ± SD, n=6, t: 90 days for polymeric delivery systems; Solution group (Insulin dispersed in PBS, injected via SC route), Cmax, Tmax, and AUC0-t for solution group: 55.75±6.4 μU/ml, 1 h, and 6.18±0.35 μU.day/ml, respectively]